Upcon® upconverting nanoparticle (UCNP) technology

Unique labeling technology with exceptional sensitivity

Upcon® upconverting nanoparticle (UCNP) system is a comprehensive concept built around a novel labeling technology based on photon upconversion. The Upcon system is a one-of-a-kind complete solution that includes brightly luminescent upconverting nanoparticles, easy-to-use and robust instruments, software, and technical support bringing the great benefits of the technology to research laboratories and point-of-care applications.

Upcon eliminates autofluorescence and scattered excitation light, offering a unique concept with high sensitivity and great performance for life science applications, research, and diagnostics. The sensitivity of Upcon is several hundred-fold higher compared to lateral flow assay formats based on visual detection.

In Upcon, the label is excited at long wavelengths—near-infrared excitation (NIR; λ = 980 nm)—and emission is detected at shorter, visible wavelengths (VIS). As a result, autofluorescence will not disturb detection at visible wavelengths and thus the emission signal is exceptionally clear.

In Upcon, the label is excited at long wavelengths (NIR, near-infrared excitation) and emission is detected at shorter wavelengths (VIS, visible light).

Upcon® enables measurement without photobleaching, self-quenching, or autofluorescence. Green curve, emission signal; yellow line, laser excitation; blue curve, autofluorescence.

Key facts

  • Exceptional labeling technology utilizing brightly luminescent Upcon® upconverting nanoparticles (UCNPs)
  • Sensitive detection even through tissue and in whole blood
  • Measurement without photobleaching, self-quenching, or autofluorescence
  • Bright luminescence with discrete emission bands and unprecedented assay sensitivity

The Upcon technology and readers were jointly developed by Kaivogen and Labrox, both now part of Uniogen. OEM solutions are also available—contact us for more information!

Read more about Upcon particles and Upcon plate readers.